The Santa Ysabel Tribal Cannabis Regulatory Agency (TCRA), a component of the Iipay Nation Tribal government, is the primary agency responsible for the regulation and legal compliance of the operators comprising the Santa Ysabel Botanical Facility.

The Santa Ysabel TCRA is dedicated to maximum consumer protection of cannabis enterprise operations authorized on Iipay Nation Tribal lands, and the safety and security of the Santa Ysabel Botanical Facility and the Tribe's retail establishment.